Focus on the pathological changes that occur in the brain – Alzheimer’s disease

We know that Alzheimer’s Disease is characterised by specific pathological changes that occur inside the brain which were originally described by Dr Alois Alzheimer and scientists now believe that these pathological changes begin in middle age and accumulate slowly.

What are these pathological changes?

Pathological changes include those that happen at the macroscopic level, which involves shrinkage or atrophy of the brain, and this can affect certain structures of the cerebral cortex, including the frontal lobe, temporal lobe and parietal lobe.

Pathological changes also occur at the microscopic level, and these are neurofibrillary tangles and amyloid plaques.

Listen to the audio below to learn more about these pathological changes